The effect of polysaccharides Calamus on the occurrence of tumors of the liver and esophagus induced by N-nitrosodiethylamine in rats was studied. The experiment was conducted on 32 male rats of Wistar line. Animals were divided into 2 groups: group I (n = 16) – animals received only carcinogen 100 mg / l daily for 4 months and Group II (n = 16) – the animals treated with the carcinogen along polysaccharides calamus marsh at a dose of 75 mg/kg of body weight daily for 6 months. Fallen in the course of the experiment the animals were opened. At the end of the experiment the liver and esophagus of all animals were subjected to macro- and microscopic examination. The obtained findings suggest that the ability of polysaccharides exert anticarcinogenic effects on the liver and esophagus cancer, appears to reduce the incidence of malignant tumors, multiple tumors and inhibition of malignancy neoplastic changes in them.
Malignant neoplasm of liver and esophagus, polysaccharides calamus, N-nitrosodiethylamine.
1. Bakal N. N. Issledovanie parametrov vydeleniya polisakharidnogo kompleksa iz aira bolotnogo //Mat. vseross. 71 itogovoy stud. nauchn. konf. im. N. I. Pirogova. Tomsk, 2012. S. 215.
2. Besednova N. N. i dr. Immunotropnye svoystva 1-3; 1-6-v-D-glyukanov. Antibiotiki i khimioterapiya, 2000. № 2. S. 37-44.
3. Birk R. V., Kil´dema L. A., Terras L. E. Vliyanie askorbinovoy kisloty na gepatokantserogennoe deystvie N-nitrozodietilamina u krys. Eksperim. onkol., 1988. T. 10, № 6. S. 66-68.
4. Lopatina K. A., Gur´ev A. M. Vliyanie vodorastvorimykh polisakharidnykh kompleksov rastitel´nogo proiskhozhdeniya na effektivnost´ tsitostaticheskoy terapii perevivaemykh opukholey. Aktual´nye problemy eksperimental´noy i klinicheskoy farmakologii: mat. konf. Tomsk, 2005. S. 23-25.
5. Razina T. G. Fitopreparaty i biologicheski aktivnye veshchestva lekarstvennykh rasteniy v kompleksnoy terapii zlokachestvennykh novoobrazovaniy (eksperimental´noe issledovanie): dis.... dokt. biol. nauk.Tomsk, 2006. 336 s.
